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Saturday, March 9, 2013

Greedy Lying Bastards (Powerlineblog)

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'Switch' critical to wound healing identified

Mar. 8, 2013 ? .Scientists from A*STAR's Institute of Medical Biology (IMB) have identified a molecular "switch" that controls the migration of skin cells necessary for wounds to close and heal. This is especially significant for diabetics and other patients who suffer from chronic wounds, wounds that do not heal or take years to do so, which are vulnerable to infections and could lead to amputations. This switch mechanism may hold the key to developing therapeutics that will reduce or prevent chronic wounds.

The scientists discovered that a tiny "micro-RNA" molecule, called miR-198, controls several different processes that help wound healing, by keeping them switched off in healthy skin. When skin is wounded, the manufacture of miR-198 quickly stops and the levels of miR-198 drop, switching on many wound healing processes.

In the non-healing wounds of diabetics, miR-198 does not disappear and wound healing remains blocked. This therefore identifies miR-198 as a potential diagnostic biomarker for non-healing wounds.

These findings were recently published in the journal Nature. The research leading to this discovery was carried out in collaboration with A*STAR's Bioinformatics Institute (BII), National University Hospital (NUH), Singapore and Jnana Sanjeevini Diabetes Center, Bangalore, India.

Importance of this discovery

Chronic wounds in patients with diabetes are a major global health burden and the most common cause of lower extremity amputations. In Singapore, diabetes is the fifth most common medical condition diagnosed and one in nine people aged 18 to 69 has diabetes. Unfortunately, chronic wounds are currently poorly understood and insufficiently treated. Chronic wounds also tend to affect the elderly and disabled patients, especially those confined to a wheelchair or bed-bound.

Dr. Prabha Sampath said, "Moving forward, we hope to translate this research into improved patient outcomes. We can now build on this research, to see how we can modulate the defective switch in chronic wounds by targeting miR-198 and its interacting molecules, to develop new strategies for treating chronic wounds."

Professor Birgitte Lane, Executive Director of IMB, said, "This switch appears to be an entirely new regulatory component in wound healing, and probably a very important one. Poor wound healing is a major healthcare burden, and this discovery is particularly timely in the face of aging populations and the sharp global rise in diabetes. The finding gives us a platform from which to develop therapies that could significantly reduce chronic wounds and improve healthcare."

An FSTL1-miR-198 molecular 'see-saw' switch

The information necessary to expressmicroRNA-198 (miR-198) and follistatin-like 1 (FSTL1) protein are found in a single "message" produced by the cell. However, miR-198 and FSTL1 protein cannot be produced at the same time -- it can only be one or the other. These two molecules also have opposite roles: miR-198 (found in unwounded skin) inhibits skin cell migration and wound healing, whereas FSTL1 protein (expressed after injury) promotes skin cell migration and wound healing. A regulatory switch dictates their expression, and hence controls the "see-saw" between inactive resting skin cells and the cell migration necessary for wound healing.

Dr. Sampath and her team showed that healthy unwounded skin contained high levels of miR-198 but no FSTL1 protein. They demonstrated that these high levels of miR-198 prevent skin cell migration by suppressing several genes, such as PLAU, LAMC2 and DIAPH1, which are needed for different aspects of the wound healing process. However upon injury, miR-198 is switched off in the wound by a signal from transforming growth factor ?1 (TGF-?1). This allows FSTL1 to now be made instead, and the skin migration genes to be unblocked, promoting migration of skin cells into the wound area to drive skin wound healing.

The scientists further examined skin samples of chronic non-healing ulcer wounds from patients with diabetes mellitus. They observed that, unlike healthy skin that had been injured, there remained high levels of miR-198 (inhibiting skin cell migration and wound healing) and an absence of FSTL1 protein (promoting skin cell migration upon wounding), indicating that this "switch" is defective in chronic wounds.

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Story Source:

The above story is reprinted from materials provided by Agency for Science, Technology and Research (A*STAR), Singapore.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Gopinath M. Sundaram, John E. A. Common, Felicia E. Gopal, Satyanarayana Srikanta, Krishnaswamy Lakshman, Declan P. Lunny, Thiam C. Lim, Vivek Tanavde, E. Birgitte Lane, Prabha Sampath. ?See-saw? expression of microRNA-198 and FSTL1 from a single transcript in wound healing. Nature, 2013; 495 (7439): 103 DOI: 10.1038/nature11890

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/kakCBhSuJCA/130308111307.htm

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The Science of Aging

If your face is wrinkling, joints are creaking and eyesight failing, it's time to face facts: you're getting old. But what causes ageing, anyway, and why is it so damn inevitable? More »


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Friday, March 8, 2013

China aims to pacify middle class; boosts defense

AP

A vendor watches the live telecast of the annual government work report by outgoing Premier Wen Jiabao on a television in a vegetable market in Fuyang in central China's Anhui province on Tuesday.

By Eric Baculinao, Bureau Chief, NBC News

BEIJING ? China pledged to tackle problems which threaten to alienate the country's growing middle class and aspirational masses as?its once-in-a-decade changing of the guard at the top of the country?s government got under way.

"We should unwaveringly combat corruption, strengthen political integrity, establish institutions to end the excessive concentration of power and lack of checks on power and ensure that officials are honest, government is clean and political affairs are handled with integrity,"said China's outgoing premier Wen Jiabao at the China?s National People?s Congress (NPC).


Wen on Tuesday enumerated major domestic challenges that have caused public discontent in recent years ? air pollution, toxic factories, tainted food and abuses of power ? and pledged more resources to environmental protection and public welfare. His speech was a tacit admission that quality of life had been sidelined by a focus on breakneck economic growth.

"We are keenly aware we still face many difficulties and problems in our economic and social development," said the premier, whose family was accused in a New York Times report late last year of amassing billions of dollars in assets.?

While the Chinese leadership also announced a boost in defense spending, the focus of this year?s Congress appeared to be decidedly domestic.

Widening inequality and a more discontented middle class were the big issues facing new leaders, said Damien Ma, analyst at the Paulson Institute, an independent think-tank.

"The problem is whether China can address the costs of that growth and seriously face the growing social cleavages that such growth has wrought,"?he said. ?

The rhetoric about improving the quality of life was not new, said Susan Shirk, an expert on Chinese politics and former Deputy Assistant Secretary of State during the Clinton administration.

Reuters, file

An elderly exercises in the morning as he faces chimneys emitting smoke behind buildings across the Songhua river in Jilin, Jilin province, on Feb. 24. China's new rulers will focus on consumer-led growth to narrow the gap between rich and poor while taking steps to curb pollution and graft, the government has said.

"The ... government talked about it every year at the NPC for the past 10 years," she said.

It was also unclear how far the government could go to address worries over extraordinary high levels of pollution and food safety, experts said.

A boost in budget for forces tasked with maintaining the peace at home was worth note, said Jeffrey Wasserstrom, author of "China in the 21st?Century."

China's public security budget will reach $32.6 billion, an increase of 7.9 percent, which will "improve the mechanism for ensuring funding for primary-level ... judicial and public security departments," according to a Ministry of Finance report.

A big challenge for the government, and a possible impediment to addressing environmental concerns, will be the need to maintain high rates of economic growth, according to experts.?

"The government will struggle to reconcile its environmental agenda with the resource-intensive urbanization program that is set to underpin economic growth," said Nicholas Consonery of political-risk consulting firm Eurasia.

To boost domestic consumption and mitigate the widening rich-poor divide, China plans to migrate hundreds of millions of farmers to the cities in the next ten years. With higher incomes, the urban middle class will boost domestic consumption which will underpin future economic growth.?

In addition to promising to grapple with environmental and social welfare issues, the government announced a 10.7 percent increase to its military budget, continuing the double digit increases seen in the last two decades, even as the country appeared set to see its lowest economic growth in years.?

A new aircraft carrier and stealth fighter bombers would be added to the military amid escalating maritime disputes with Japan and other Asian neighbors, the NPC announced.

The defense modernization will help to ?resolutely uphold China?s sovereignty, security and territorial integrity,? Wen said during his last work report after ten years at the helm of China?s Cabinet.

The move is seen as attempt of the new leadership headed by Party chief and incoming President Xi Jinping to project strength and forge strong ties with China?s military, a major base of support. China is now the world?s second biggest military spender with $114 billion, after the United States which spent $633 billion last year.

The ongoing military buildup was not cause for alarm, Shirk said.

?The increase is consistent with past budgets... Roughly in line with economic growth. Not a massive military buildup,? she said.

Related:

Chinese ex-police detained while trying to stamp out corruption

Notorious drug lord executed by China over 'Golden Triangle' smuggling, hijackings

China's Anti-Corruption Drive Hits New Year Sales

Source: http://behindthewall.nbcnews.com/_news/2013/03/06/17209529-china-seeks-to-pacify-middle-class-boosts-defense-spending?lite

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Thursday, March 7, 2013

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Unapologetic fangirl: eats fic for breakfast, lunch and dinner. Loves Teen Wolf, SPN, Rome and Breaking bad. Likes noisy music, misery, steak and lickable abs.



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Five facts about the daylight saving time change

A clock hangs in Plantation, Fla. (Joe Raedle/Getty Images)

Here's everything you wanted to know about the time change this weekend.

When is it?
The time change begins on Sunday, March 10, at 2 a.m., when clocks are moved forward by one hour.

Why 2 a.m.?
The time change is set for 2 a.m. because it was decided to be the least disruptive time of day. Moving time forward or back an hour at that time doesn?t change the date, which avoids confusion, and most people are asleep, or if people do work on a Sunday, it?s usually later than 2 a.m.

Do all states observe daylight saving time?
Hawaii and most of Arizona don?t observe the time change. U.S. territories that don?t go on daylight saving time include American Samoa, Guam, Puerto Rico and the Virgin Islands.

Why do we have it?
The idea is to save electricity because there are more hours of natural light. Studies have shown the savings to be fairly nominal?the time change leading people to switch on the lights earlier in the morning instead or cranking up the air conditioning, for example.

What is the history of daylight saving time?
Fun fact: The idea was first floated in 1784 by one Benjamin Franklin. While minister of France, he wrote the essay "An Economical Project for Diminishing the Cost of Light."

The idea failed to see the light of day until 1883, when the U.S. railroads instituted a standardized time for their train schedules. That time change was imposed nationally during the First World War to conserve energy, but it was repealed after the war. It became the national time again during World War II.

After that, it was up to the states to decide if they wanted it, and when it would start and end. Congress finally enacted the Uniform Time Act in 1966, which standardized the beginning and end of daylight time for the states that observed it. In 1974 and 1975, the energy crisis moved Congress to enact earlier daylight start times, which were reversed when the crisis was over.

Daylight saving time since then had always been in April?until the Energy Policy Act of 2005 ordered the earlier start time to begin in March 2007.

Source: http://news.yahoo.com/blogs/lookout/time-spring-forward-five-facts-daylight-saving-time-223010524.html

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